2,5,6-trichloronicotinoyl chloride - Names and Identifiers
2,5,6-trichloronicotinoyl chloride - Physico-chemical Properties
| Molecular Formula | C6HCl4NO
|
| Molar Mass | 244.89 |
| Density | 1.689±0.06 g/cm3(Predicted) |
| Melting Point | 38-39 °C |
| Boling Point | 87-88 °C(Press: 0.15 Torr) |
| pKa | -6.58±0.10(Predicted) |
2,5,6-trichloronicotinoyl chloride - Upstream Downstream Industry
2,5,6-trichloronicotinoyl chloride - Introduction
2,5,6-trichloronicotinoyl chloride(2,5,6-trichloronicotinoyl chloride) is an organic compound with the chemical formula C6H2Cl3NOCl. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2,5, 6-tricloronicotinoyl chloride is a colorless to pale yellow powder.
-Melting point: About 100-102 ° C.
-Boiling Point: Not applicable.
-Density: Not applicable.
-Solubility: 2,5,6-trichloronicotinoyl chloride is poorly soluble in water, but can be dissolved in organic solvents.
Use:
-Chemical synthesis: 2,5,6-trichloronicotinoyl chloride is an important reagent in organic synthesis. It is commonly used in synthetic drugs, insecticides, pesticides and other chemicals. For example, it can be used to synthesize nicotine-like compounds.
-Chemical research: 2,5, 6-tricloronicotinoyl chloride can also be used for specific functional group transformations in organic synthesis reactions.
Method:
2,5,6-trichloronicotinoyl chloride is prepared as follows:
1. Thionyl chloride method: First, 3-chloropyridine is reacted with nitrosyl chloride to obtain 3-chloropyridine-2, 6-dione. The 3-chloropyridine-2, 6-dione is then reacted with sulfuryl chloride to give 2,5,6-trichloronicotinoyl chloride.
2. Thionyl chloride reduction method: First, 3-chloropyridine is reacted with nitrosyl chloride to obtain 3-chloropyridine-2, 6-dione. Then, 3-chloropyridine-2, 6-dione was reacted with thionyl chloride and reduced to give 2,5,6-trichloronicotinoyl chloride.
Safety Information:
- 2,5,6-trichloronicotinoyl chloride is a harmful substance that may cause harm to human health. Contact with skin, eyes and respiratory tract should be avoided. Wear appropriate protective equipment such as gloves, goggles and masks during operation.
- 2,5,6-trichloronicotinoyl chloride should be kept away from fire and oxidant, and used in a well-ventilated area. During storage and handling, the relevant safety procedures and regulations shall be observed.
Please note that this information is for reference only, and the product manual and relevant safety data sheet should be read carefully before actual use.
Last Update：2024-04-09 21:01:54